Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability.
Deja S, Fletcher JA, Kim CW, Kucejova B, Fu X, Mizerska M, Villegas M, Pudelko-Malik N, Browder N, Inigo-Vollmer M, Menezes CJ, Mishra P, Berglund ED, Browning JD, Thyfault JP, Young JD, Horton JD, Burgess SC.
Cell Metab. 2024 May 7;36(5):1088-1104.e12. doi: 10.1016/j.cmet.2024.02.004. Epub 2024 Mar 5.
Integrated transcriptomics, proteomics and metabolomics-based analysis uncover TAM2-associated glycolysis and pyruvate metabolic remodeling in pancreatic cancer.
Li X, Du Y, Jiang W, Dong S, Li W, Tang H, Yi J, Zhou W, Zhang H.
Front Immunol. 2023 Aug 17;14:1170223. doi: 10.3389/fimmu.2023.1170223. eCollection 2023.
Endogenous renal adiponectin drives gluconeogenesis through enhancing pyruvate and fatty acid utilization.
Onodera T, Wang MY, Rutkowski JM, Deja S, Chen S, Balzer MS, Kim DS, Sun X, An YA, Field BC, Lee C, Matsuo EI, Mizerska M, Sanjana I, Fujiwara N, Kusminski CM, Gordillo R, Gautron L, Marciano DK, Hu MC, Burgess SC, Susztak K, Moe OW, Scherer PE.
Nat Commun. 2023 Oct 17;14(1):6531. doi: 10.1038/s41467-023-42188-4.
Comprehensive review on lactate metabolism in human health.
Adeva-Andany M, López-Ojén M, Funcasta-Calderón R, Ameneiros-Rodríguez E, Donapetry-García C, Vila-Altesor M, Rodríguez-Seijas J.
Mitochondrion. 2014 Jul;17:76-100. doi: 10.1016/j.mito.2014.05.007. Epub 2014 Jun 12.
Disruption of hepatic mitochondrial pyruvate and amino acid metabolism impairs gluconeogenesis and endurance exercise capacity in mice.
Martino MR, Habibi M, Ferguson D, Brookheart RT, Thyfault JP, Meyer GA, Lantier L, Hughey CC, Finck BN.
Am J Physiol Endocrinol Metab. 2024 Apr 1;326(4):E515-E527. doi: 10.1152/ajpendo.00258.2023. Epub 2024 Feb 14.
The SLC25A47 locus controls gluconeogenesis and energy expenditure.
Yook JS, Taxin ZH, Yuan B, Oikawa S, Auger C, Mutlu B, Puigserver P, Hui S, Kajimura S.
Proc Natl Acad Sci U S A. 2023 Feb 28;120(9):e2216810120. doi: 10.1073/pnas.2216810120. Epub 2023 Feb 22.
Branched-chain keto acids inhibit mitochondrial pyruvate carrier and suppress gluconeogenesis in hepatocytes.
Nishi K, Yoshii A, Abell L, Zhou B, Frausto R, Ritterhoff J, McMillen TS, Sweet I, Wang Y, Gao C, Tian R.
Cell Rep. 2023 Jun 27;42(6):112641. doi: 10.1016/j.celrep.2023.112641. Epub 2023 Jun 12.
Roles of malate and aspartate in gluconeogenesis in various physiological and pathological states.
Holeček M.
Metabolism. 2023 Aug;145:155614. doi: 10.1016/j.metabol.2023.155614. Epub 2023 Jun 5.
G protein-coupled receptor 151 regulates glucose metabolism and hepatic gluconeogenesis.
Bielczyk-Maczynska E, Zhao M, Zushin PH, Schnurr TM, Kim HJ, Li J, Nallagatla P, Sangwung P, Park CY, Cornn C, Stahl A, Svensson KJ, Knowles JW.
Nat Commun. 2022 Dec 1;13(1):7408. doi: 10.1038/s41467-022-35069-9.
Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult.
Yiew NKH, Vazquez JH, Martino MR, Kennon-McGill S, Price JR, Allard FD, Yee EU, Layman AJ, James LP, McCommis KS, Finck BN, McGill MR.
Mol Metab. 2023 Nov;77:101808. doi: 10.1016/j.molmet.2023.101808. Epub 2023 Sep 15.
