How to think about acute leukemia of ambiguous lineage.
Weinberg OK.
Hematology Am Soc Hematol Educ Program. 2024 Dec 6;2024(1):287-292. doi: 10.1182/hematology.2024000554.
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How I Diagnose Acute Leukemia of Ambiguous Lineage.
Weinberg OK, Arber DA.
Am J Clin Pathol. 2022 Jul 1;158(1):27-34. doi: 10.1093/ajcp/aqac070.
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Project EVOLVE: an international analysis of postimmunotherapy lineage switch, an emergent form of relapse in leukemia.
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Venetoclax plus gilteritinib is effective in preclinical models of FLT3-mutant BCL11B-a lineage-ambiguous leukemia.
Montefiori LE, Iacobucci I, Gao Q, Moore J, Wright WC, Wei H, Baviskar P, Sona S, Jin H, Budhraja A, Lott J, Tatarata QZ, Cheng Z, Khan T, Backhaus Wagner EA, Johnson M, Mehr CM, Freeman B, Janke L, Haferlach T, Geeleher P, Mead PE, Konopleva M, Opferman JT, Mullighan CG.
Blood. 2025 Nov 6;146(19):2350-2356. doi: 10.1182/blood.2025028985.
PMID:40811853
14q32 rearrangements deregulating BCL11B mark a distinct subgroup of T-lymphoid and myeloid immature acute leukemia.
Di Giacomo D, La Starza R, Gorello P, Pellanera F, Kalender Atak Z, De Keersmaecker K, Pierini V, Harrison CJ, Arniani S, Moretti M, Testoni N, De Santis G, Roti G, Matteucci C, Bassan R, Vandenberghe P, Aerts S, Cools J, Bornhauser B, Bourquin JP, Piazza R, Mecucci C.
International cooperative study identifies treatment strategy in childhood ambiguous lineage leukemia.
Hrusak O, de Haas V, Stancikova J, Vakrmanova B, Janotova I, Mejstrikova E, Capek V, Trka J, Zaliova M, Luks A, Bleckmann K, Möricke A, Irving J, Konatkowska B, Alexander TB, Inaba H, Schmiegelow K, Stokley S, Zemanova Z, Moorman AV, Rossi JG, Felice MS, Dalla-Pozza L, Morales J, Dworzak M, Buldini B, Basso G, Campbell M, Cabrera ME, Marinov N, Elitzur S, Izraeli S, Luria D, Feuerstein T, Kolenova A, Svec P, Kreminska O, Rabin KR, Polychronopoulou S, da Costa E, Marquart HV, Kattamis A, Ratei R, Reinhardt D, Choi JK, Schrappe M, Stary J.
Blood. 2018 Jul 19;132(3):264-276. doi: 10.1182/blood-2017-12-821363. Epub 2018 May 2.
Acute Leukemias of Ambiguous Lineage With RUNX1 Mutations Show Similar Prognosis Compared to Acute Myeloid Leukemia With RUNX1 Mutations: A Study From the Bone Marrow Pathology Group.
Kirtek TJ, Chen W, Harris JC, Bagg A, Foucar K, Tam W, Orazi A, Hsi ED, Hasserjian RP, Wang SA, Ng DP, George TI, Shi M, Reichard KK, Symes E, Zhang X, Arber DA, Weinberg OK.
Am J Hematol. 2026 Jan;101(1):70-78. doi: 10.1002/ajh.70116. Epub 2025 Oct 18.
PMID:41108621
Mixed-phenotype acute leukemia: A cohort and consensus research strategy from the Children's Oncology Group Acute Leukemia of Ambiguous Lineage Task Force.
Orgel E, Alexander TB, Wood BL, Kahwash SB, Devidas M, Dai Y, Alonzo TA, Mullighan CG, Inaba H, Hunger SP, Raetz EA, Gamis AS, Rabin KR, Carroll AJ 3rd, Heerema NA, Berman JN, Woods WG, Loh ML, Zweidler-McKay PA, Horan JT; Children's Oncology Group Acute Leukemia of Ambiguous Lineage Task Force.
Cancer. 2020 Feb 1;126(3):593-601. doi: 10.1002/cncr.32552. Epub 2019 Oct 29.
PMID:31661160
Cytoplasmic CD3 expression in infant acute megakaryoblastic leukemia: A new ambiguous lineage subtype?
Rossi JG, Rubio P, Alonso CN, Bernasconi AR, Sajaroff EO, Digiorge J, Baialardo E, Eandi-Eberle S, Guitter M, Fernandez-Barbieri A, Mitchell R, Felice MS.
Leuk Res. 2018 Aug;71:6-12. doi: 10.1016/j.leukres.2018.05.009. Epub 2018 Jun 18.