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Selumetinib in Children with Inoperable Plexiform Neurofibromas.
Gross AM, Wolters PL, Dombi E, Baldwin A, Whitcomb P, Fisher MJ, Weiss B, Kim A, Bornhorst M, Shah AC, Martin S, Roderick MC, Pichard DC, Carbonell A, Paul SM, Therrien J, Kapustina O, Heisey K, Clapp DW, Zhang C, Peer CJ, Figg WD, Smith M, Glod J, Blakeley JO, Steinberg SM, Venzon DJ, Doyle LA, Widemann BC.
N Engl J Med. 2020 Apr 9;382(15):1430-1442. doi: 10.1056/NEJMoa1912735. Epub 2020 Mar 18.
PMID:32187457
Humanized neurofibroma model from induced pluripotent stem cells delineates tumor pathogenesis and developmental origins.
Mo J, Anastasaki C, Chen Z, Shipman T, Papke J, Yin K, Gutmann DH, Le LQ.
J Clin Invest. 2021 Jan 4;131(1):e139807. doi: 10.1172/JCI139807.
PMID:33108355
Histopathologic evaluation of atypical neurofibromatous tumors and their transformation into malignant peripheral nerve sheath tumor in patients with neurofibromatosis 1-a consensus overview.
Miettinen MM, Antonescu CR, Fletcher CDM, Kim A, Lazar AJ, Quezado MM, Reilly KM, Stemmer-Rachamimov A, Stewart DR, Viskochil D, Widemann B, Perry A.
Hum Pathol. 2017 Sep;67:1-10. doi: 10.1016/j.humpath.2017.05.010. Epub 2017 May 24.
PMID:28551330
Neuronal hyperexcitability drives central and peripheral nervous system tumor progression in models of neurofibromatosis-1.
Anastasaki C, Mo J, Chen JK, Chatterjee J, Pan Y, Scheaffer SM, Cobb O, Monje M, Le LQ, Gutmann DH.
Nat Commun. 2022 May 19;13(1):2785. doi: 10.1038/s41467-022-30466-6.
PMID:35589737
Cellular Origin, Tumor Progression, and Pathogenic Mechanisms of Cutaneous Neurofibromas Revealed by Mice with Nf1 Knockout in Boundary Cap Cells.
Radomska KJ, Coulpier F, Gresset A, Schmitt A, Debbiche A, Lemoine S, Wolkenstein P, Vallat JM, Charnay P, Topilko P.
Cancer Discov. 2019 Jan;9(1):130-147. doi: 10.1158/2159-8290.CD-18-0156. Epub 2018 Oct 22.
PMID:30348676
Neurocutaneous disorders.
Barbagallo JS, Kolodzieh MS, Silverberg NB, Weinberg JM.
Dermatol Clin. 2002 Jul;20(3):547-60, viii. doi: 10.1016/s0733-8635(02)00005-0.
PMID:12170887
Neurofibromatosis type 1.
Anderson JL, Gutmann DH.
Handb Clin Neurol. 2015;132:75-86. doi: 10.1016/B978-0-444-62702-5.00004-4.
PMID:26564071
Plexiform neurofibromas.
Korf BR.
Am J Med Genet. 1999 Mar 26;89(1):31-7. doi: 10.1002/(sici)1096-8628(19990326)89:1<31::aid-ajmg7>3.0.co;2-w.
PMID:10469434
Neurofibroma and schwannoma.
Ferner RE, O'Doherty MJ.
Curr Opin Neurol. 2002 Dec;15(6):679-84. doi: 10.1097/01.wco.0000044763.39452.aa.
PMID:12447105
THE UVEA.
KAUFMAN HE.
Arch Ophthalmol. 1965 Mar;73:420-9. doi: 10.1001/archopht.1965.00970030422022.
PMID:14246199
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