Scleral structure and biomechanics.
Boote C, Sigal IA, Grytz R, Hua Y, Nguyen TD, Girard MJA.
Prog Retin Eye Res. 2020 Jan;74:100773. doi: 10.1016/j.preteyeres.2019.100773. Epub 2019 Aug 11.
Macrophage extracellular traps as key mediators of scleral remodeling in myopia induced by hypoxia and activated platelets.
Feng Q, Yuan J, Hu Y, Feng C, Lin X, Liu S, Ji S, Mao X, Lin X, Cong J, Li X, Li X, Li H, Yan D, Dai J.
Cell Rep. 2025 Jun 24;44(6):115771. doi: 10.1016/j.celrep.2025.115771. Epub 2025 May 28.
Scleral hypoxia is a target for myopia control.
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Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):E7091-E7100. doi: 10.1073/pnas.1721443115. Epub 2018 Jul 9.
Management of scleral melt.
Ahearn BE, Lewis KE, Reynolds BE, Kheirkhah A.
Ocul Surf. 2023 Jan;27:92-99. doi: 10.1016/j.jtos.2022.12.005. Epub 2022 Dec 19.
Covariation of scleral remodeling and PI3K/Akt signaling pathway in experimental myopia.
Li X, Liu X, Yu Y, Li T, Guo L, Hu G, Wei H, Yang Z, Liu J, Hao Y, Zhang R, Wu Q, Liao X, Guo D, Bi H.
Sci Rep. 2025 Apr 11;15(1):12476. doi: 10.1038/s41598-025-97643-7.
Quercetin Alleviates Scleral Remodeling Through Inhibiting the PERK-EIF2alpha Axis in Experiment Myopia.
Zhang M, Zhang R, Hao J, Zhao X, Ma Z, Peng Y, Bao B, Xin J, Yin X, Bi H, Guo D.
Invest Ophthalmol Vis Sci. 2024 Nov 4;65(13):11. doi: 10.1167/iovs.65.13.11.
Extracellular Matrix Stiffness Modulates Myopia Scleral Remodeling Through Integrin/F-Actin/YAP Axis.
Liu X, Yuan Y, Wu Y, Zhu C, Liu Y, Ke B.
Invest Ophthalmol Vis Sci. 2025 Feb 3;66(2):22. doi: 10.1167/iovs.66.2.22.
Decreased scleral Wnt5a(hi) fibroblasts exacerbate myopia progression by disrupting extracellular matrix homeostasis in mice.
Zhu H, Chen W, Ling X, Jiao S, Yu L, Liu H, Ding M, Zhang F, Zhou Y, Pan Y, Zhou Z, Qu J, Zhao F, Zhao F, Zhou X.
Nat Commun. 2025 Dec 16;17(1):554. doi: 10.1038/s41467-025-67246-x.
The miR-15b-5p/miR-379-3p-FOXO axis regulates cell cycle and apoptosis in scleral remodeling during experimental myopia.
Zhang R, Wen Y, Liu J, Hao J, Peng Y, Zhang M, Xie Y, Yang Z, Yin X, Shi Y, Bi H, Guo D.
J Transl Med. 2024 Jul 30;22(1):710. doi: 10.1186/s12967-024-05523-x.
Scleral Proteome in Noninfectious Scleritis Unravels Upregulation of Filaggrin-2 and Signs of Neovascularization.
Vergouwen DPC, Ten Berge JC, Guzel C, van den Bosch TPP, Verdijk RM, Rothova A, Luider TM, Schreurs MWJ.
Invest Ophthalmol Vis Sci. 2023 Mar 1;64(3):27. doi: 10.1167/iovs.64.3.27.
