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hexokinase deficiency相关文献:
Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to beta-amyloid clearance.
Leng L, Yuan Z, Pan R, Su X, Wang H, Xue J, Zhuang K, Gao J, Chen Z, Lin H, Xie W, Li H, Chen Z, Ren K, Zhang X, Wang W, Jin ZB, Wu S, Wang X, Yuan Z, Xu H, Chow HM, Zhang J.
Nat Metab. 2022 Oct;4(10):1287-1305. doi: 10.1038/s42255-022-00643-4. Epub 2022 Oct 6.
PMID:36203054
Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis.
Hinrichsen F, Hamm J, Westermann M, Schröder L, Shima K, Mishra N, Walker A, Sommer N, Klischies K, Prasse D, Zimmermann J, Kaiser S, Bordoni D, Fazio A, Marinos G, Laue G, Imm S, Tremaroli V, Basic M, Häsler R, Schmitz RA, Krautwald S, Wolf A, Stecher B, Schmitt-Kopplin P, Kaleta C, Rupp J, Bäckhed F, Rosenstiel P, Sommer F.
Cell Metab. 2021 Dec 7;33(12):2355-2366.e8. doi: 10.1016/j.cmet.2021.11.004. Epub 2021 Nov 29.
PMID:34847376
Early life high fructose impairs microglial phagocytosis and neurodevelopment.
Wang Z, Lipshutz A, Martínez de la Torre C, Trzeciak AJ, Liu ZL, Miranda IC, Lazarov T, Codo AC, Romero-Pichardo JE, Nair A, Schild T, Saitz Rojas W, Saavedra PHV, Baako AK, Fadojutimi K, Downey MS, Geissmann F, Faraco G, Gan L, Etchegaray JI, Lucas CD, Tanasova M, Parkhurst CN, Zeng MY, Keshari KR, Perry JSA.
Nature. 2025 Aug;644(8077):759-768. doi: 10.1038/s41586-025-09098-5. Epub 2025 Jun 11.
PMID:40500435
NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity.
Gu M, Zhou X, Sohn JH, Zhu L, Jie Z, Yang JY, Zheng X, Xie X, Yang J, Shi Y, Brightbill HD, Kim JB, Wang J, Cheng X, Sun SC.
Nat Immunol. 2021 Feb;22(2):193-204. doi: 10.1038/s41590-020-00829-6. Epub 2021 Jan 4.
PMID:33398181
Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin.
DeWaal D, Nogueira V, Terry AR, Patra KC, Jeon SM, Guzman G, Au J, Long CP, Antoniewicz MR, Hay N.
Nat Commun. 2018 Jan 31;9(1):446. doi: 10.1038/s41467-017-02733-4.
PMID:29386513
L-arginine homeostasis governs adult neural stem cell activation by modulating energy metabolism in vivo.
Xu M, Guo Y, Wang M, Luo X, Shen X, Li Z, Wang L, Guo W.
EMBO J. 2023 Mar 15;42(6):e112647. doi: 10.15252/embj.2022112647. Epub 2023 Feb 6.
PMID:36740997
Aerobic glycolysis enhances HBx-initiated hepatocellular carcinogenesis via NF-κBp65/HK2 signalling.
Chen L, Lin X, Lei Y, Xu X, Zhou Q, Chen Y, Liu H, Jiang J, Yang Y, Zheng F, Wu B.
J Exp Clin Cancer Res. 2022 Nov 21;41(1):329. doi: 10.1186/s13046-022-02531-x.
PMID:36411480
FGF-dependent metabolic control of vascular development.
Yu P, Wilhelm K, Dubrac A, Tung JK, Alves TC, Fang JS, Xie Y, Zhu J, Chen Z, De Smet F, Zhang J, Jin SW, Sun L, Sun H, Kibbey RG, Hirschi KK, Hay N, Carmeliet P, Chittenden TW, Eichmann A, Potente M, Simons M.
Nature. 2017 May 11;545(7653):224-228. doi: 10.1038/nature22322. Epub 2017 May 3.
PMID:28467822
Deficiency of rice hexokinase HXK5 impairs synthesis and utilization of starch in pollen grains and causes male sterility.
Lee SK, Kim H, Cho JI, Nguyen CD, Moon S, Park JE, Park HR, Huh JH, Jung KH, Guiderdoni E, Jeon JS.
J Exp Bot. 2020 Jan 1;71(1):116-125. doi: 10.1093/jxb/erz436.
PMID:31671177
Transcription factor Tox2 is required for metabolic adaptation and tissue residency of ILC3 in the gut.
Das A, Martinez-Ruiz GU, Bouladoux N, Stacy A, Moraly J, Vega-Sendino M, Zhao Y, Lavaert M, Ding Y, Morales-Sanchez A, Harly C, Seedhom MO, Chari R, Awasthi P, Ikeuchi T, Wang Y, Zhu J, Moutsopoulos NM, Chen W, Yewdell JW, Shapiro VS, Ruiz S, Taylor N, Belkaid Y, Bhandoola A.
Immunity. 2024 May 14;57(5):1019-1036.e9. doi: 10.1016/j.immuni.2024.04.001. Epub 2024 Apr 26.
PMID:38677292
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