Antibiotics-first strategy for uncomplicated acute appendicitis in adults is associated with increased rates of peritonitis at surgery. A systematic review with meta-analysis of randomized controlled trials comparing appendectomy and non-operative management with antibiotics.
Podda M, Cillara N, Di Saverio S, Lai A, Feroci F, Luridiana G, Agresta F, Vettoretto N; ACOI (Italian Society of Hospital Surgeons) Study Group on Acute Appendicitis.
Surgeon. 2017 Oct;15(5):303-314. doi: 10.1016/j.surge.2017.02.001. Epub 2017 Mar 9.
PMID:28284517
Predictors of Complicated Appendicitis with Evolution to Appendicular Peritonitis in Pediatric Patients.