A Bispecific Monoclonal Antibody Targeting Psl and PcrV Enhances Neutrophil-Mediated Killing of Pseudomonas aeruginosa in Patients with Bronchiectasis.
Long MB, Gilmour A, Kehl M, Tabor DE, Keller AE, Warrener P, Gopalakrishnan V, Rosengren S, Crichton ML, McIntosh E, Giam YH, Keir HR, Brailsford W, Hughes R, Belvisi MG, Sellman BR, DiGiandomenico A, Chalmers JD.
Am J Respir Crit Care Med. 2024 Jul 1;210(1):35-46. doi: 10.1164/rccm.202308-1403OC.
PMID:38754132
Phenotypical characteristics of nontuberculous mycobacterial infection in patients with bronchiectasis.
Frajman A, Izhakian S, Mekiten O, Hadar O, Lichtenstadt A, Hajaj C, Shchori S, Heching M, Rosengarten D, Kramer MR.
A gut Eggerthella lenta-derived metabolite impairs neutrophil function to aggravate bacterial lung infection.
Wang LL, Shen X, Xie Y, Ge A, Lu H, Gu S, Kong L, Narayana JK, Mattner J, Chotirmall SH, Xu JF.
Sci Transl Med. 2025 Feb 26;17(787):eadq4409. doi: 10.1126/scitranslmed.adq4409. Epub 2025 Feb 26.
PMID:40009694
Endotypes of Pseudomonas aeruginosa Infection in Bronchiectasis Are Associated with Inhaled Antibiotic Response: Results from Two Randomized, Double-Blind, Placebo-controlled Phase III Trials (ORBIT 3 and ORBIT 4).
Hull RC, Stobo J, Abo-Leyah H, Richardson H, Alferes de Lima Headley D, Long MB, Hennayake C, Gilmour A, Johnson ED, Tunney M, Dicker AJ, Kewin E, Huang JTJ, Haworth CS, Chalmers JD.
Am J Respir Crit Care Med. 2025 Aug;211(8):1397-1408. doi: 10.1164/rccm.202501-0159OC.
PMID:40664229
Atorvastatin in Bronchiectasis With Chronic Pseudomonas Infection.