PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation.
Xie M, Yu Y, Kang R, Zhu S, Yang L, Zeng L, Sun X, Yang M, Billiar TR, Wang H, Cao L, Jiang J, Tang D.
Nat Commun. 2016 Oct 25;7:13280. doi: 10.1038/ncomms13280.
Genomic responses in mouse models poorly mimic human inflammatory diseases.
Seok J, Warren HS, Cuenca AG, Mindrinos MN, Baker HV, Xu W, Richards DR, McDonald-Smith GP, Gao H, Hennessy L, Finnerty CC, López CM, Honari S, Moore EE, Minei JP, Cuschieri J, Bankey PE, Johnson JL, Sperry J, Nathens AB, Billiar TR, West MA, Jeschke MG, Klein MB, Gamelli RL, Gibran NS, Brownstein BH, Miller-Graziano C, Calvano SE, Mason PH, Cobb JP, Rahme LG, Lowry SF, Maier RV, Moldawer LL, Herndon DN, Davis RW, Xiao W, Tompkins RG; Inflammation and Host Response to Injury, Large Scale Collaborative Research Program.
Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3507-12. doi: 10.1073/pnas.1222878110. Epub 2013 Feb 11.
Extracellular NCOA4 is a mediator of septic death by activating the AGER-NFKB pathway.
Liu J, Wang Y, Zeng L, Yu C, Kang R, Klionsky DJ, Jiang J, Tang D.
Autophagy. 2024 Dec;20(12):2616-2631. doi: 10.1080/15548627.2024.2372215. Epub 2024 Jul 4.
Are the Outcomes of a Pig Endotoxemia Model Applicable to Human Sepsis?
Lyons NB, Proctor KG.
Crit Care Med. 2023 Aug 1;51(8):1102-1104. doi: 10.1097/CCM.0000000000005904. Epub 2023 Jul 13.
1,25-Dihydroxyvitamin D3 reduces early mortality post severe burn injury via alleviating endotoxemia, oxidative stress and inflammation.
Chen Y, Guo JH, Chen YJ, Huang Y, Zhang C, Zhang Q, Gong YL, Chen J.
Burns. 2024 Sep;50(7):1790-1798. doi: 10.1016/j.burns.2024.05.009. Epub 2024 May 8.
Myocardial pyruvate dehydrogenase kinase 4 drives sex-specific cardiac responses to endotoxemia.
Yap JQ, Nikouee A, Kim M, Cao Q, Rademacher DJ, Lau JE, Arora A, Zou LY, Sun Y, Szweda L, Sadek H, Elliot S, Roos B, Glassberg MK, Ji HL, Gao X, Dong Q, Zang QS.
JCI Insight. 2025 Jul 8;10(13):e191649. doi: 10.1172/jci.insight.191649. eCollection 2025 Jul 8.
Neutrophil migration during endotoxemia.
Wagner JG, Roth RA.
J Leukoc Biol. 1999 Jul;66(1):10-24. doi: 10.1002/jlb.66.1.10.
Cardiolipin oxidized by ROS from complex II acts as a target of gasdermin D to drive mitochondrial pore and heart dysfunction in endotoxemia.
Tang Y, Wu J, Sun X, Tan S, Li W, Yin S, Liu L, Chen Y, Liu Y, Tan Q, Jiang Y, Yang W, Huang W, Weng C, Wu Q, Lu Y, Yuan H, Xiao Q, Chen AF, Xu Q, Billiar TR, Cai J.
Cell Rep. 2024 May 28;43(5):114237. doi: 10.1016/j.celrep.2024.114237. Epub 2024 May 15.
Experimental human endotoxemia as a model of systemic inflammation.
van Lier D, Geven C, Leijte GP, Pickkers P.
Biochimie. 2019 Apr;159:99-106. doi: 10.1016/j.biochi.2018.06.014. Epub 2018 Jun 22.
Nucleolin alleviates endotoxemia-induced myocardial dysfunction via inhibiting Drp1-mediated mitochondrial fission.
Yuan L, Tang Y, Yin L, Lin X, Liang P, Jiang B.
Tissue Cell. 2025 Oct;96:102964. doi: 10.1016/j.tice.2025.102964. Epub 2025 May 18.
