Intermittent dietary methionine deprivation facilitates tumoral ferroptosis and synergizes with checkpoint blockade.
Xue Y, Lu F, Chang Z, Li J, Gao Y, Zhou J, Luo Y, Lai Y, Cao S, Li X, Zhou Y, Li Y, Tan Z, Cheng X, Li X, Chen J, Wang W.
Nat Commun. 2023 Aug 8;14(1):4758. doi: 10.1038/s41467-023-40518-0.
PRMT1 orchestrates with SAMTOR to govern mTORC1 methionine sensing via Arg-methylation of NPRL2.
Jiang C, Liu J, He S, Xu W, Huang R, Pan W, Li X, Dai X, Guo J, Zhang T, Inuzuka H, Wang P, Asara JM, Xiao J, Wei W.
Cell Metab. 2023 Dec 5;35(12):2183-2199.e7. doi: 10.1016/j.cmet.2023.11.001. Epub 2023 Nov 24.
Methionine deficiency facilitates antitumour immunity by altering m(6)A methylation of immune checkpoint transcripts.
Li T, Tan YT, Chen YX, Zheng XJ, Wang W, Liao K, Mo HY, Lin J, Yang W, Piao HL, Xu RH, Ju HQ.
Gut. 2023 Mar;72(3):501-511. doi: 10.1136/gutjnl-2022-326928. Epub 2022 Jul 8.
Methionine oxidation in bacteria: A reversible post-translational modification.
Vincent MS, Ezraty B.
Mol Microbiol. 2023 Feb;119(2):143-150. doi: 10.1111/mmi.15000. Epub 2022 Nov 22.
Cysteine and methionine oxidation in thrombotic disorders.
Yang M, Smith BC.
Curr Opin Chem Biol. 2023 Oct;76:102350. doi: 10.1016/j.cbpa.2023.102350. Epub 2023 Jun 16.
Methionine restriction-induced sulfur deficiency impairs antitumour immunity partially through gut microbiota.
Ji M, Xu X, Xu Q, Hsiao YC, Martin C, Ukraintseva S, Popov V, Arbeev KG, Randall TA, Wu X, Garcia-Peterson LM, Liu J, Xu X, Andrea Azcarate-Peril M, Wan Y, Yashin AI, Anantharaman K, Lu K, Li JL, Shats I, Li X.
Nat Metab. 2023 Sep;5(9):1526-1543. doi: 10.1038/s42255-023-00854-3. Epub 2023 Aug 3.
The methionine cycle and its cancer implications.
Tassinari V, Jia W, Chen WL, Candi E, Melino G.
Oncogene. 2024 Nov;43(48):3483-3488. doi: 10.1038/s41388-024-03122-0. Epub 2024 Oct 11.
Methionine secreted by tumor-associated pericytes supports cancer stem cells in clear cell renal carcinoma.
Zhang C, Du Z, Gao Y, Lim KS, Zhou W, Huang H, He H, Xiao J, Xu D, Li Q.
Cell Metab. 2024 Apr 2;36(4):778-792.e10. doi: 10.1016/j.cmet.2024.01.018. Epub 2024 Feb 19.
Methionine consumption by cancer cells drives a progressive upregulation of PD-1 expression in CD4 T cells.
Pandit M, Kil YS, Ahn JH, Pokhrel RH, Gu Y, Mishra S, Han Y, Ouh YT, Kang B, Jeong MS, Kim JO, Nam JW, Ko HJ, Chang JH.
Nat Commun. 2023 May 5;14(1):2593. doi: 10.1038/s41467-023-38316-9.
Methionine-Restricted Diet: A Feasible Strategy Against Chronic or Aging-Related Diseases.
Wu G, Xu J, Wang Q, Fang Z, Fang Y, Jiang Y, Zhang X, Cheng X, Sun J, Le G.
J Agric Food Chem. 2023 Jan 11;71(1):5-19. doi: 10.1021/acs.jafc.2c05829. Epub 2022 Dec 26.
