Induction of SOX17 with stimulation of WNT, TGF-beta, and FGF signaling drives embryonal carcinomas into the yolk-sac tumor lineage resulting in increased cisplatin resistance.
Kotthoff M, Skowron MA, Bremmer F, Parmaksiz F, Kretschmer P, Stephan A, Fichtner A, Lautwein T, Raba K, Fuß J, Köhrer K, Nettersheim D.
Int J Cancer. 2025 Jun 1;156(11):2210-2224. doi: 10.1002/ijc.35385. Epub 2025 Mar 2.
PMID:40025812
Is fertility sparing surgery a treatment option for young patients with yolk sac tumor?