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Metformin-induced vitamin B12 deficiency can cause or worsen distal symmetrical, autonomic and cardiac neuropathy in the patient with diabetes.
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Metformin-Induced Vitamin B12 Deficiency in Patients With Type-2 Diabetes Mellitus.
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Cureus. 2023 Oct 26;15(10):e47771. doi: 10.7759/cureus.47771. eCollection 2023 Oct.
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Pratama S, Lauren BC, Wisnu W.
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Long-term Metformin Use and Vitamin B12 Deficiency in the Diabetes Prevention Program Outcomes Study.
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Nutritional peripheral neuropathies.
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B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin.
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Association between neuropathy and B-vitamins: A systematic review and meta-analysis.
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Postpartum peripheral neuropathy due to vitamin B12 deficiency, potentially precipitated by nitrous oxide use.
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Anaesth Rep. 2023 May 14;11(1):e12229. doi: 10.1002/anr3.12229. eCollection 2023 Jan-Jun.
