Lung infection by Pseudomonas aeruginosa induces neuroinflammation and blood-brain barrier dysfunction in mice.
Villalba N, Ma Y, Gahan SA, Joly-Amado A, Spence S, Yang X, Nash KR, Yuan SY.
J Neuroinflammation. 2023 May 27;20(1):127. doi: 10.1186/s12974-023-02817-7.
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Mechanical activation of lung epithelial cells through the ion channel Piezo1 activates the metalloproteinases ADAM10 and ADAM17 and promotes growth factor and adhesion molecule release.
Grannemann C, Pabst A, Honert A, Schieren J, Martin C, Hank S, Böll S, Bläsius K, Düsterhöft S, Jahr H, Merkel R, Leube R, Babendreyer A, Ludwig A.
Biomater Adv. 2023 Sep;152:213516. doi: 10.1016/j.bioadv.2023.213516. Epub 2023 Jun 12.
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IL-4 and IL-13, not eosinophils, drive type 2 airway inflammation, remodeling and lung function decline.
Scott G, Asrat S, Allinne J, Keat Lim W, Nagashima K, Birchard D, Srivatsan S, Ajithdoss DK, Oyejide A, Ben LH, Walls J, Le Floc'h A, Yancopoulos GD, Murphy AJ, Sleeman MA, Orengo JM.
Cytokine. 2023 Feb;162:156091. doi: 10.1016/j.cyto.2022.156091. Epub 2022 Dec 5.
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Endothelialized Bronchioalveolar Lung Organoids Model Endothelial Cell Responses to Injury.
Ament AL, Heiner M, Hessler MC, Alexopoulos I, Steeg K, Gärtner U, Vazquez-Armendariz AI, Herold S.
Am J Respir Cell Mol Biol. 2025 Feb;72(2):124-132. doi: 10.1165/rcmb.2023-0373MA.
PMID:39226154
Hemoglobin increases leukocyte adhesion and initiates lung microvascular endothelial activation via Toll-like receptor 4 signaling.
Conger AK, Tomasek T, Riedmann KJ, Douglas JS, Berkey LE, Ware LB, Bastarache JA, Meegan JE.
Am J Physiol Cell Physiol. 2023 Mar 1;324(3):C665-C673. doi: 10.1152/ajpcell.00211.2022. Epub 2023 Jan 30.
PMID:36717098
Intestinal lymph-borne factors induce lung release of inflammatory mediators and expression of adhesion molecules after an intestinal ischemic insult.
Breithaupt-Faloppa AC, Vitoretti LB, Cavriani G, Lino-dos-Santos-Franco A, Sudo-Hayashi LS, Oliveira-Filho RM, Vargaftig BB, Tavares-de-Lima W.