The role of macrophages in obesity-associated islet inflammation and beta-cell abnormalities.
Ying W, Fu W, Lee YS, Olefsky JM.
Nat Rev Endocrinol. 2020 Feb;16(2):81-90. doi: 10.1038/s41574-019-0286-3. Epub 2019 Dec 13.
Glucocorticoids and beta-cell function.
Fichna M, Fichna P.
Endokrynol Pol. 2017;68(5):568-573. doi: 10.5603/EP.2017.0060.
Interruption of glucagon signaling augments islet non-alpha cell proliferation in SLC7A2- and mTOR-dependent manners.
Coate KC, Dai C, Singh A, Stanley J, Covington BA, Bradley A, Oladipupo F, Gong Y, Wisniewski S, Sellick K, Spears E, Poffenberger G, Schornack AMR, Bustabad A, Rodgers T, Dey N, Shultz LD, Greiner DL, Yan H, Powers AC, Chen W, Dean ED.
Mol Metab. 2024 Dec;90:102050. doi: 10.1016/j.molmet.2024.102050. Epub 2024 Oct 20.
Pathologic pancreatic endocrine cell hyperplasia.
Ouyang D, Dhall D, Yu R.
World J Gastroenterol. 2011 Jan 14;17(2):137-43. doi: 10.3748/wjg.v17.i2.137.
Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia.
Bernal-Mizrachi E, Wen W, Stahlhut S, Welling CM, Permutt MA.
J Clin Invest. 2001 Dec;108(11):1631-8. doi: 10.1172/JCI13785.
Liver-derived Neuregulin1alpha stimulates compensatory pancreatic beta cell hyperplasia in insulin resistance.
Arai T, Hayashi E, Maeda S, Matsubara T, Fujii H, Shinohara K, Sogabe A, Wainai S, Tanaka D, Ono Y, Ono Y, Yoshikai M, Sorimachi Y, Kok CY, Shimoda M, Tanaka M, Kawada N, Goda N.
Nat Commun. 2025 Mar 13;16(1):1950. doi: 10.1038/s41467-025-57167-0.
Islet beta-cell regeneration and reg genes.
Unno M, Itoh T, Watanabe T, Miyashita H, Moriizumi S, Teraoka H, Yonekura H, Okamoto H.
Adv Exp Med Biol. 1992;321:61-6; discussion 67-9. doi: 10.1007/978-1-4615-3448-8_8.
beta-Cell Fate in Human Insulin Resistance and Type 2 Diabetes: A Perspective on Islet Plasticity.
Mezza T, Cinti F, Cefalo CMA, Pontecorvi A, Kulkarni RN, Giaccari A.
Diabetes. 2019 Jun;68(6):1121-1129. doi: 10.2337/db18-0856.
gamma-aminobutyric acid modulates alpha-cell hyperplasia but not beta-cell regeneration induced by glucagon receptor antagonism in type 1 diabetic mice.
Gu L, Cui X, Lin X, Yang J, Wei R, Hong T, Yang K.
Acta Diabetol. 2023 Jan;60(1):19-28. doi: 10.1007/s00592-022-01970-4. Epub 2022 Sep 21.
Clinical PET imaging of insulinoma and beta-cell hyperplasia.
Kauhanen S, Seppänen M, Minn H, Nuutila P.
Curr Pharm Des. 2010 May;16(14):1550-60. doi: 10.2174/138161210791164090.
