PPIL4 is essential for brain angiogenesis and implicated in intracranial aneurysms in humans.
Barak T, Ristori E, Ercan-Sencicek AG, Miyagishima DF, Nelson-Williams C, Dong W, Jin SC, Prendergast A, Armero W, Henegariu O, Erson-Omay EZ, Harmancı AS, Guy M, Gültekin B, Kilic D, Rai DK, Goc N, Aguilera SM, Gülez B, Altinok S, Ozcan K, Yarman Y, Coskun S, Sempou E, Deniz E, Hintzen J, Cox A, Fomchenko E, Jung SW, Ozturk AK, Louvi A, Bilgüvar K, Connolly ES Jr, Khokha MK, Kahle KT, Yasuno K, Lifton RP, Mishra-Gorur K, Nicoli S, Günel M.
Nat Med. 2021 Dec;27(12):2165-2175. doi: 10.1038/s41591-021-01572-7. Epub 2021 Dec 9.
PMID:34887573
Study of cerebral vascular structures in hypertensive intracerebral haemorrhage.
Pleşea IE, Cameniţă A, Georgescu CC, Enache SD, Zaharia B, Georgescu CV, Tenovici M.
Rom J Morphol Embryol. 2005;46(3):249-56.
PMID:16444313
Association between Circle of Willis Configuration and Rupture of Cerebral Aneurysms.
Stojanović NN, Kostić A, Mitić R, Berilažić L, Radisavljević M.