Lancet. 1969 Feb 8;1(7589):315-6. doi: 10.1016/s0140-6736(69)91080-0.
PMID:4179026
Adenylate kinase 4 (AK4) deficiency prevents vascular smooth muscle cell phenotypic switching by regulating mitochondrial dysfunction through AMPKalpha inactivation.
Zhang SM, Luo H, Li Z, Du M, Chen J, Jiang DS, Zhang Y, Li C, Yang X, Wang XS, Fang ZM, Gong FH, Yang J.
Atherosclerosis. 2025 Sep;408:120399. doi: 10.1016/j.atherosclerosis.2025.120399. Epub 2025 Jun 4.
PMID:40506332
The exerkine apelin reverses age-associated sarcopenia.
Vinel C, Lukjanenko L, Batut A, Deleruyelle S, Pradère JP, Le Gonidec S, Dortignac A, Geoffre N, Pereira O, Karaz S, Lee U, Camus M, Chaoui K, Mouisel E, Bigot A, Mouly V, Vigneau M, Pagano AF, Chopard A, Pillard F, Guyonnet S, Cesari M, Burlet-Schiltz O, Pahor M, Feige JN, Vellas B, Valet P, Dray C.
Adenylate kinase 1 deficiency disrupts mouse sperm motility under conditions of energy stress.
Xie M, Zhang G, Zhang H, Chen F, Chen Y, Zhuang Y, Huang Z, Zou F, Liu M, An G, Kang X, Chen Z.
Biol Reprod. 2020 Oct 29;103(5):1121-1131. doi: 10.1093/biolre/ioaa134.
PMID:32744313
Adenylate kinase 9 is essential for sperm function and male fertility in mammals.
O'Callaghan E, Navarrete-Lopez P, Štiavnická M, Sánchez JM, Maroto M, Pericuesta E, Fernández-González R, O'Meara C, Eivers B, Kelleher MM, Evans RD, Mapel XM, Lloret-Villas A, Pausch H, Balastegui-Alarcón M, Avilés M, Sanchez-Rodriguez A, Roldan ERS, McDonald M, Kenny DA, Fair S, Gutiérrez-Adán A, Lonergan P.
Proc Natl Acad Sci U S A. 2023 Oct 17;120(42):e2305712120. doi: 10.1073/pnas.2305712120. Epub 2023 Oct 9.
PMID:37812723
Deficiency in AK9 causes asthenozoospermia and male infertility by destabilising sperm nucleotide homeostasis.
Sha Y, Liu W, Li S, Osadchuk LV, Chen Y, Nie H, Gao S, Xie L, Qin W, Zhou H, Li L.