Adenylate kinase 4 (AK4) deficiency prevents vascular smooth muscle cell phenotypic switching by regulating mitochondrial dysfunction through AMPKalpha inactivation.
Zhang SM, Luo H, Li Z, Du M, Chen J, Jiang DS, Zhang Y, Li C, Yang X, Wang XS, Fang ZM, Gong FH, Yang J.
Atherosclerosis. 2025 Sep;408:120399. doi: 10.1016/j.atherosclerosis.2025.120399. Epub 2025 Jun 4.
The exerkine apelin reverses age-associated sarcopenia.
Vinel C, Lukjanenko L, Batut A, Deleruyelle S, Pradère JP, Le Gonidec S, Dortignac A, Geoffre N, Pereira O, Karaz S, Lee U, Camus M, Chaoui K, Mouisel E, Bigot A, Mouly V, Vigneau M, Pagano AF, Chopard A, Pillard F, Guyonnet S, Cesari M, Burlet-Schiltz O, Pahor M, Feige JN, Vellas B, Valet P, Dray C.
Nat Med. 2018 Sep;24(9):1360-1371. doi: 10.1038/s41591-018-0131-6. Epub 2018 Jul 30.
Erythrocyte adenylate-kinase deficiency.
Szeinberg A, Gavendo S, Cahane D.
Lancet. 1969 Feb 8;1(7589):315-6. doi: 10.1016/s0140-6736(69)91080-0.
Adenylate kinase 9 is essential for sperm function and male fertility in mammals.
O'Callaghan E, Navarrete-Lopez P, Štiavnická M, Sánchez JM, Maroto M, Pericuesta E, Fernández-González R, O'Meara C, Eivers B, Kelleher MM, Evans RD, Mapel XM, Lloret-Villas A, Pausch H, Balastegui-Alarcón M, Avilés M, Sanchez-Rodriguez A, Roldan ERS, McDonald M, Kenny DA, Fair S, Gutiérrez-Adán A, Lonergan P.
Proc Natl Acad Sci U S A. 2023 Oct 17;120(42):e2305712120. doi: 10.1073/pnas.2305712120. Epub 2023 Oct 9.
Metformin reverses established lung fibrosis in a bleomycin model.
Rangarajan S, Bone NB, Zmijewska AA, Jiang S, Park DW, Bernard K, Locy ML, Ravi S, Deshane J, Mannon RB, Abraham E, Darley-Usmar V, Thannickal VJ, Zmijewski JW.
Nat Med. 2018 Aug;24(8):1121-1127. doi: 10.1038/s41591-018-0087-6. Epub 2018 Jul 2.
Adenylate kinase 5 deficiency impairs epididymal white adipose tissue homeostasis and decreases fat mass.
Hwang S, Kim J, Seong JK.
J Vet Sci. 2025 Jan;26(1):e5. doi: 10.4142/jvs.24269. Epub 2024 Dec 18.
Adenylate kinase 1 deficiency disrupts mouse sperm motility under conditions of energy stress .
Xie M, Zhang G, Zhang H, Chen F, Chen Y, Zhuang Y, Huang Z, Zou F, Liu M, An G, Kang X, Chen Z.
Biol Reprod. 2020 Oct 29;103(5):1121-1131. doi: 10.1093/biolre/ioaa134.
[Adenylate kinase deficiency].
Matsuura S, Nakazawa A.
Tanpakushitsu Kakusan Koso. 1988 Apr;33(5):610-4.
Adenylate Kinase and Metabolic Signaling in Cancer Cells.
Klepinin A, Zhang S, Klepinina L, Rebane-Klemm E, Terzic A, Kaambre T, Dzeja P.
Front Oncol. 2020 May 19;10:660. doi: 10.3389/fonc.2020.00660. eCollection 2020.
Congenital neutropenia.
Klein C.
Hematology Am Soc Hematol Educ Program. 2009:344-50. doi: 10.1182/asheducation-2009.1.344.
