Chondrocyte-targeted exosome-mediated delivery of Nrf2 alleviates cartilaginous endplate degeneration by modulating mitochondrial fission.
Lin Z, Xu G, Lu X, Liu S, Zou F, Ma X, Jiang J, Wang H, Song J.
J Nanobiotechnology. 2024 May 24;22(1):281. doi: 10.1186/s12951-024-02517-1.
Piezo1 exacerbates inflammation-induced cartilaginous endplate degeneration by activating mitochondrial fission via the Ca(2+)/CaMKII/Drp1 axis.
Lin Z, Xu G, Lu X, Wang H, Lu F, Xia X, Song J, Jiang J, Ma X, Zou F.
Aging Cell. 2025 Apr;24(4):e14440. doi: 10.1111/acel.14440. Epub 2024 Nov 28.
A human organoid drug screen identifies alpha2-adrenergic receptor signaling as a therapeutic target for cartilage regeneration.
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Cell Stem Cell. 2024 Dec 5;31(12):1813-1830.e8. doi: 10.1016/j.stem.2024.09.001. Epub 2024 Sep 30.
Shared and Compartment-Specific Processes in Nucleus Pulposus and Annulus Fibrosus During Intervertebral Disc Degeneration.
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Adv Sci (Weinh). 2024 May;11(17):e2309032. doi: 10.1002/advs.202309032. Epub 2024 Feb 25.
A plant-derived natural photosynthetic system for improving cell anabolism.
Chen P, Liu X, Gu C, Zhong P, Song N, Li M, Dai Z, Fang X, Liu Z, Zhang J, Tang R, Fan S, Lin X.
Nature. 2022 Dec;612(7940):546-554. doi: 10.1038/s41586-022-05499-y. Epub 2022 Dec 7.
Engineered human osteoarthritic cartilage organoids.
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Biomaterials. 2024 Jul;308:122549. doi: 10.1016/j.biomaterials.2024.122549. Epub 2024 Mar 22.
The roles of the Hippo-YAP signalling pathway in Cartilage and Osteoarthritis.
Sun K, Guo J, Guo Z, Hou L, Liu H, Hou Y, He J, Guo F, Ye Y.
Ageing Res Rev. 2023 Sep;90:102015. doi: 10.1016/j.arr.2023.102015. Epub 2023 Jul 14.
Propionibacterium acnes induces cartilaginous endplate degeneration by promoting MIF expression via the NF-kappaB pathway.
Zhang Y, Wang Y, Yuan Y, Lin Y, Lin B, Zhou H.
J Orthop Surg Res. 2020 Jun 9;15(1):213. doi: 10.1186/s13018-020-01714-6.
Ultrashort time-to-echo MR morphology of cartilaginous endplate correlates with disc degeneration in the lumbar spine.
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Eur Spine J. 2023 Jul;32(7):2358-2367. doi: 10.1007/s00586-023-07739-9. Epub 2023 May 17.
Chlorogenic Acid retards cartilaginous endplate degeneration and ameliorates intervertebral disc degeneration via suppressing NF-kappaB signaling.
Ge Q, Ying J, Shi Z, Mao Q, Jin H, Wang PE, Chen J, Yuan W, Tong P, Li J.
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