Mild Hypercapnia or Normocapnia after Out-of-Hospital Cardiac Arrest.
Eastwood G, Nichol AD, Hodgson C, Parke RL, McGuinness S, Nielsen N, Bernard S, Skrifvars MB, Stub D, Taccone FS, Archer J, Kutsogiannis D, Dankiewicz J, Lilja G, Cronberg T, Kirkegaard H, Capellier G, Landoni G, Horn J, Olasveengen T, Arabi Y, Chia YW, Markota A, Hænggi M, Wise MP, Grejs AM, Christensen S, Munk-Andersen H, Granfeldt A, Andersen GØ, Qvigstad E, Flaa A, Thomas M, Sweet K, Bewley J, Bäcklund M, Tiainen M, Iten M, Levis A, Peck L, Walsham J, Deane A, Ghosh A, Annoni F, Chen Y, Knight D, Lesona E, Tlayjeh H, Svenšek F, McGuigan PJ, Cole J, Pogson D, Hilty MP, Düring JP, Bailey MJ, Paul E, Ady B, Ainscough K, Hunt A, Monahan S, Trapani T, Fahey C, Bellomo R; TAME Study Investigators.
N Engl J Med. 2023 Jul 6;389(1):45-57. doi: 10.1056/NEJMoa2214552. Epub 2023 Jun 15.
High-flow nasal cannula versus conventional oxygen therapy in acute COPD exacerbation with mild hypercapnia: a multicenter randomized controlled trial.
Xia J, Gu S, Lei W, Zhang J, Wei H, Liu C, Zhang H, Lu R, Zhang L, Jiang M, Hu C, Cheng Z, Wei C, Chen Y, Lu F, Chen M, Bi H, Liu H, Yan C, Teng H, Yang Y, Liang C, Ge Y, Hou P, Liu J, Gao W, Zhang Y, Feng Y, Tao C, Huang X, Pan P, Luo H, Yun C, Zhan Q.
Crit Care. 2022 Apr 15;26(1):109. doi: 10.1186/s13054-022-03973-7.
Obstructive sleep apnoea syndrome.
Lévy P, Kohler M, McNicholas WT, Barbé F, McEvoy RD, Somers VK, Lavie L, Pépin JL.
Nat Rev Dis Primers. 2015 Jun 25;1:15015. doi: 10.1038/nrdp.2015.15.
Impact of normocapnia vs. mild hypercapnia on prognosis after cardiac arrest: A systematic review and meta-analysis.
Zhong S, Yang Y, Peng W, Li W, Wang L, Zheng D, Wang DC, Xia X, Tan Y.
Am J Emerg Med. 2025 Apr;90:1-8. doi: 10.1016/j.ajem.2024.12.060. Epub 2024 Dec 27.
Mild and moderate chronic hypercapnia elicit distinct transcriptomic responses of immune function in cardiorespiratory nuclei.
Grams KJ, Neumueller SE, Mouradian GC Jr, Burgraff NJ, Hodges MR, Pan L, Forster HV.
Physiol Genomics. 2023 Nov 1;55(11):487-503. doi: 10.1152/physiolgenomics.00038.2023. Epub 2023 Aug 21.
Targeted mild hypercapnia and acute kidney failure after cardiac arrest: Lessons from the TAME trial.
Lascarrou JB, Canet E.
Resuscitation. 2025 Feb;207:110505. doi: 10.1016/j.resuscitation.2025.110505. Epub 2025 Jan 21.
Postresuscitation management.
Behringer W, Skrifvars MB, Taccone FS.
Curr Opin Crit Care. 2023 Dec 1;29(6):640-647. doi: 10.1097/MCC.0000000000001116. Epub 2023 Oct 12.
Mild hypercapnia improves brain tissue oxygen tension but not diffusion limitation in asphyxial cardiac arrest: an experimental study in pigs.
Zhou D, Li Z, Zhang S, Wu L, Li Y, Shi G, Zhou J.
BMC Anesthesiol. 2020 Sep 29;20(1):252. doi: 10.1186/s12871-020-01162-z.
Mild hypercapnia before reperfusion reduces ischemia-reperfusion injury in hyperacute ischemic stroke rat model.
Jung JW, Yoon CE, Kwon I, Lee KO, Kim J, Kim YD, Heo JH, Nam HS.
J Cereb Blood Flow Metab. 2025 Apr;45(4):664-676. doi: 10.1177/0271678X241296367. Epub 2024 Oct 30.
Hypercapnia: An Aggravating Factor in Asthma.
Shigemura M, Homma T, Sznajder JI.
J Clin Med. 2020 Oct 5;9(10):3207. doi: 10.3390/jcm9103207.
