Mild Hypercapnia or Normocapnia after Out-of-Hospital Cardiac Arrest.
Eastwood G, Nichol AD, Hodgson C, Parke RL, McGuinness S, Nielsen N, Bernard S, Skrifvars MB, Stub D, Taccone FS, Archer J, Kutsogiannis D, Dankiewicz J, Lilja G, Cronberg T, Kirkegaard H, Capellier G, Landoni G, Horn J, Olasveengen T, Arabi Y, Chia YW, Markota A, Hænggi M, Wise MP, Grejs AM, Christensen S, Munk-Andersen H, Granfeldt A, Andersen GØ, Qvigstad E, Flaa A, Thomas M, Sweet K, Bewley J, Bäcklund M, Tiainen M, Iten M, Levis A, Peck L, Walsham J, Deane A, Ghosh A, Annoni F, Chen Y, Knight D, Lesona E, Tlayjeh H, Svenšek F, McGuigan PJ, Cole J, Pogson D, Hilty MP, Düring JP, Bailey MJ, Paul E, Ady B, Ainscough K, Hunt A, Monahan S, Trapani T, Fahey C, Bellomo R; TAME Study Investigators.
N Engl J Med. 2023 Jul 6;389(1):45-57. doi: 10.1056/NEJMoa2214552. Epub 2023 Jun 15.
High-flow nasal cannula versus conventional oxygen therapy in acute COPD exacerbation with mild hypercapnia: a multicenter randomized controlled trial.
Xia J, Gu S, Lei W, Zhang J, Wei H, Liu C, Zhang H, Lu R, Zhang L, Jiang M, Hu C, Cheng Z, Wei C, Chen Y, Lu F, Chen M, Bi H, Liu H, Yan C, Teng H, Yang Y, Liang C, Ge Y, Hou P, Liu J, Gao W, Zhang Y, Feng Y, Tao C, Huang X, Pan P, Luo H, Yun C, Zhan Q.
Crit Care. 2022 Apr 15;26(1):109. doi: 10.1186/s13054-022-03973-7.
Obstructive sleep apnoea syndrome.
Lévy P, Kohler M, McNicholas WT, Barbé F, McEvoy RD, Somers VK, Lavie L, Pépin JL.
Nat Rev Dis Primers. 2015 Jun 25;1:15015. doi: 10.1038/nrdp.2015.15.
Impact of normocapnia vs. mild hypercapnia on prognosis after cardiac arrest: A systematic review and meta-analysis.
Zhong S, Yang Y, Peng W, Li W, Wang L, Zheng D, Wang DC, Xia X, Tan Y.
Am J Emerg Med. 2025 Apr;90:1-8. doi: 10.1016/j.ajem.2024.12.060. Epub 2024 Dec 27.
Is sustained hypercapnia required to initiate plasticity in humans exposed to mild intermittent hypoxia?
Mateika JH, Barok R, Kissane DM.
J Physiol. 2024 Oct;602(20):5125-5128. doi: 10.1113/JP287341. Epub 2024 Aug 17.
Mild and moderate chronic hypercapnia elicit distinct transcriptomic responses of immune function in cardiorespiratory nuclei.
Grams KJ, Neumueller SE, Mouradian GC Jr, Burgraff NJ, Hodges MR, Pan L, Forster HV.
Physiol Genomics. 2023 Nov 1;55(11):487-503. doi: 10.1152/physiolgenomics.00038.2023. Epub 2023 Aug 21.
Targeted mild hypercapnia and acute kidney failure after cardiac arrest: Lessons from the TAME trial.
Lascarrou JB, Canet E.
Resuscitation. 2025 Feb;207:110505. doi: 10.1016/j.resuscitation.2025.110505. Epub 2025 Jan 21.
Postresuscitation management.
Behringer W, Skrifvars MB, Taccone FS.
Curr Opin Crit Care. 2023 Dec 1;29(6):640-647. doi: 10.1097/MCC.0000000000001116. Epub 2023 Oct 12.
Interesting associations between hypercapnia and myocardial injury seen in the targeted therapeutic mild hypercapnia after resuscitated cardiac arrest trial.
Skrifvars MB.
Resuscitation. 2024 Aug;201:110321. doi: 10.1016/j.resuscitation.2024.110321. Epub 2024 Jul 17.
Impact of mild hypercapnia on renal function after out-of-hospital cardiac arrest.
Eastwood GM, Bailey M, Nichol AD, Parke R, Nielsen N, Dankiewicz J, Bellomo R; TAME trial investigators.
Resuscitation. 2025 Feb;207:110480. doi: 10.1016/j.resuscitation.2024.110480. Epub 2024 Dec 30.
