Calcified apoptotic vesicles from PROCR(+) fibroblasts initiate heterotopic ossification.
Yan J, Gao B, Wang C, Lu W, Qin W, Han X, Liu Y, Li T, Guo Z, Ye T, Wan Q, Xu H, Kang J, Lu N, Gao C, Qin Z, Yang C, Zheng J, Shen P, Niu L, Zou W, Jiao K.
J Extracell Vesicles. 2024 Apr;13(4):e12425. doi: 10.1002/jev2.12425.
FOXO1 regulates RUNX2 ubiquitination through SMURF2 in calcific aortic valve disease.
Jiang C, Yao D, Liu Z, Zheng Y, Chen M, Yim WY, Zheng Q, Zhang T, Fan L, Fan Z, Geng B, Tian R, Zhou T, Qiao W, Shi J, Li F, Xu L, Huang Y, Dong N.
Redox Biol. 2024 Jul;73:103215. doi: 10.1016/j.redox.2024.103215. Epub 2024 May 27.
TRIB3 mediates vascular calcification by facilitating self-ubiquitination and dissociation of Smurf1 in chronic kidney disease.
Li Y, Ma C, Sheng Y, Huang S, Sun H, Ti Y, Wang Z, Wang F, Chen F, Li C, Guo H, Tang M, Song F, Wang H, Zhong M.
J Clin Invest. 2025 Apr 1;135(7):e175972. doi: 10.1172/JCI175972.
AVCAPIR: A Novel Procalcific PIWI-Interacting RNA in Calcific Aortic Valve Disease.
Han D, Zhou T, Li L, Ma Y, Chen S, Yang C, Ma N, Song M, Zhang S, Wu J, Cao F, Wang Y.
Circulation. 2024 May 14;149(20):1578-1597. doi: 10.1161/CIRCULATIONAHA.123.065213. Epub 2024 Jan 23.
Spatiotemporal and microstructural characterization of heterotopic ossification in healing rat Achilles tendons.
Pierantoni M, Hammerman M, Silva Barreto I, Larsson D, Notermans T, Bodey AJ, Eliasson P, Isaksson H.
FASEB J. 2023 Jun;37(6). doi: 10.1096/fj.202201018RRR.
Calcific aortic valve disease: from molecular and cellular mechanisms to medical therapy.
Kraler S, Blaser MC, Aikawa E, Camici GG, Lüscher TF.
Eur Heart J. 2022 Feb 12;43(7):683-697. doi: 10.1093/eurheartj/ehab757.
Morusin Alleviates Aortic Valve Calcification by Inhibiting Valve Interstitial Cell Senescence Through Ccnd1/Trim25/Nrf2 Axis.
Liu Z, Wang K, Jiang C, Chen Y, Liu F, Xie M, Yim WY, Yao D, Qian X, Chen S, Shi J, Xu K, Wang Y, Dong N.
Adv Sci (Weinh). 2024 May;11(20):e2307319. doi: 10.1002/advs.202307319. Epub 2024 Mar 19.
ALKBH1-demethylated DNA N6-methyladenine modification triggers vascular calcification via osteogenic reprogramming in chronic kidney disease.
Ouyang L, Su X, Li W, Tang L, Zhang M, Zhu Y, Xie C, Zhang P, Chen J, Huang H.
J Clin Invest. 2021 Jul 15;131(14):e146985. doi: 10.1172/JCI146985.
Trimethylamine-N-Oxide Promotes Vascular Calcification Through Activation of NLRP3 (Nucleotide-Binding Domain, Leucine-Rich-Containing Family, Pyrin Domain-Containing-3) Inflammasome and NF-kappaB (Nuclear Factor kappaB) Signals.
Zhang X, Li Y, Yang P, Liu X, Lu L, Chen Y, Zhong X, Li Z, Liu H, Ou C, Yan J, Chen M.
Arterioscler Thromb Vasc Biol. 2020 Mar;40(3):751-765. doi: 10.1161/ATVBAHA.119.313414. Epub 2020 Jan 16.
Enhancing aortic valve drug delivery with PAR2-targeting magnetic nano-cargoes for calcification alleviation.
Chen J, Ren T, Xie L, Hu H, Li X, Maitusong M, Zhou X, Hu W, Xu D, Qian Y, Cheng S, Yu K, Wang JA, Liu X.
Nat Commun. 2024 Jan 16;15(1):557. doi: 10.1038/s41467-024-44726-0.
