High level positive end expiratory pressure (PEEP) in acute respiratory insufficiency.
Releasing high positive end-expiratory pressure to a low level generates a pronounced increase in particle flow from the airways.
Controlled ventilation with best positive end-expiratory pressure (PEEP) and high level PEEP in acute respiratory failure (ARF).
High versus low positive end-expiratory pressure during general anaesthesia for open abdominal surgery (PROVHILO trial): a multicentre randomised controlled trial.
PROVE Network Investigators for the Clinical Trial Network of the European Society of Anaesthesiology; Hemmes SN, Gama de Abreu M, Pelosi P, Schultz MJ.
Lancet. 2014 Aug 9;384(9942):495-503. doi: 10.1016/S0140-6736(14)60416-5. Epub 2014 Jun 2.
High versus low positive end-expiratory pressure (PEEP) levels for mechanically ventilated adult patients with acute lung injury and acute respiratory distress syndrome.
Santa Cruz R, Villarejo F, Irrazabal C, Ciapponi A.
Cochrane Database Syst Rev. 2021 Mar 30;3(3):CD009098. doi: 10.1002/14651858.CD009098.pub3.
High positive end-expiratory pressure ventilation mitigates the progression from unilateral pulmonary contusion to ARDS: An animal study.
Landeck T, Schwarz H, Hammermüller S, Noreikat K, Reske S, Gottschaldt U, Nestler C, Wolf SJ, Ramm J, Lange M, Wrigge H, Girrbach F, Brehm W, Reske AW.
J Trauma Acute Care Surg. 2024 Feb 1;96(2):287-296. doi: 10.1097/TA.0000000000004077. Epub 2023 Jun 19.
Preoxygenation and prevention of desaturation during emergency airway management.
Weingart SD, Levitan RM.
Ann Emerg Med. 2012 Mar;59(3):165-75.e1. doi: 10.1016/j.annemergmed.2011.10.002. Epub 2011 Nov 3.
High-level positive end expiratory pressure management in the surgical patient with acute respiratory distress syndrome.
Safcsak K, Nelson LD.
AACN Clin Issues. 1996 Nov;7(4):482-94; quiz 642-4. doi: 10.1097/00044067-199611000-00003.
Ventilation-induced acute kidney injury in acute respiratory failure: Do PEEP levels matter?
Benites MH, Suarez-Sipmann F, Kattan E, Cruces P, Retamal J.
Crit Care. 2025 Mar 21;29(1):130. doi: 10.1186/s13054-025-05343-5.
High-inflation pressure and positive end-expiratory pressure. Injurious to the lung? No.
Nelson LD.
Crit Care Clin. 1996 Jul;12(3):603-25. doi: 10.1016/s0749-0704(05)70265-7.
High Positive End-Expiratory Pressure Renders Spontaneous Effort Noninjurious.
Morais CCA, Koyama Y, Yoshida T, Plens GM, Gomes S, Lima CAS, Ramos OPS, Pereira SM, Kawaguchi N, Yamamoto H, Uchiyama A, Borges JB, Vidal Melo MF, Tucci MR, Amato MBP, Kavanagh BP, Costa ELV, Fujino Y.
Am J Respir Crit Care Med. 2018 May 15;197(10):1285-1296. doi: 10.1164/rccm.201706-1244OC.
Association between driving pressure and development of postoperative pulmonary complications in patients undergoing mechanical ventilation for general anaesthesia: a meta-analysis of individual patient data.
Neto AS, Hemmes SN, Barbas CS, Beiderlinden M, Fernandez-Bustamante A, Futier E, Gajic O, El-Tahan MR, Ghamdi AA, Günay E, Jaber S, Kokulu S, Kozian A, Licker M, Lin WQ, Maslow AD, Memtsoudis SG, Reis Miranda D, Moine P, Ng T, Paparella D, Ranieri VM, Scavonetto F, Schilling T, Selmo G, Severgnini P, Sprung J, Sundar S, Talmor D, Treschan T, Unzueta C, Weingarten TN, Wolthuis EK, Wrigge H, Amato MB, Costa EL, de Abreu MG, Pelosi P, Schultz MJ; PROVE Network Investigators.
Lancet Respir Med. 2016 Apr;4(4):272-80. doi: 10.1016/S2213-2600(16)00057-6. Epub 2016 Mar 4.
High positive end expiratory pressure levels affect hemodynamics in elderly patients with hypertension admitted to the intensive care unit: a prospective cohort study.
Zhou L, Cai G, Xu Z, Weng Q, Ye Q, Chen C.
BMC Pulm Med. 2019 Nov 27;19(1):224. doi: 10.1186/s12890-019-0965-9.
