Complement C4-deficient mice have a high mortality rate during PTZ-induced epileptic seizures, which correlates with cognitive problems and the deficiency in the expression of Egr1 and other immediate early genes.
Veremeyko T, Jiang R, He M, Ponomarev ED.
Front Cell Neurosci. 2023 May 10;17:1170031. doi: 10.3389/fncel.2023.1170031. eCollection 2023.