Haploidentical transplants using ex vivo T-cell depletion.
Martelli MF, Aversa F.
Semin Hematol. 2016 Oct;53(4):252-256. doi: 10.1053/j.seminhematol.2016.07.001. Epub 2016 Jul 25.
Both intratumoral regulatory T cell depletion and CTLA-4 antagonism are required for maximum efficacy of anti-CTLA-4 antibodies.
Lax BM, Palmeri JR, Lutz EA, Sheen A, Stinson JA, Duhamel L, Santollani L, Kennedy A, Rothschilds AM, Spranger S, Sansom DM, Wittrup KD.
Proc Natl Acad Sci U S A. 2023 Aug;120(31):e2300895120. doi: 10.1073/pnas.2300895120. Epub 2023 Jul 24.
Restoration of T-cell homeostasis after T-cell depletion.
Mackall CL, Hakim FT, Gress RE.
Semin Immunol. 1997 Dec;9(6):339-46. doi: 10.1006/smim.1997.0091.
T-cell depletion for bone marrow transplantation: effects on graft rejection, graft-versus-host disease, graft-versus-leukemia, and survival.
Champlin RE.
Cancer Treat Res. 1990;50:99-111. doi: 10.1007/978-1-4613-1493-6_6.
Depletion of Ly6G-Expressing Neutrophilic Cells Leads to Altered Peripheral T-Cell Homeostasis and Thymic Development in Neonatal Mice.
Rühle J, Ginzel M, Dietz S, Schwarz J, Lajqi T, Beer-Hammer S, Poets CF, Gille C, Köstlin-Gille N.
Int J Mol Sci. 2023 Apr 24;24(9):7763. doi: 10.3390/ijms24097763.
Differential expression of CCR8 in tumors versus normal tissue allows specific depletion of tumor-infiltrating T regulatory cells by GS-1811, a novel Fc-optimized anti-CCR8 antibody.
Weaver JD, Stack EC, Buggé JA, Hu C, McGrath L, Mueller A, Wong M, Klebanov B, Rahman T, Kaufman R, Fregeau C, Spaulding V, Priess M, Legendre K, Jaffe S, Upadhyay D, Singh A, Xu CA, Krukenberg K, Zhang Y, Ezzyat Y, Saddier Axe D, Kuhne MR, Meehl MA, Shaffer DR, Weist BM, Wiederschain D, Depis F, Gostissa M.
Oncoimmunology. 2022 Nov 4;11(1):2141007. doi: 10.1080/2162402X.2022.2141007. eCollection 2022.
CD20+ B cell depletion alters T cell homing.
Kap YS, van Driel N, Laman JD, Tak PP, 't Hart BA.
J Immunol. 2014 May 1;192(9):4242-53. doi: 10.4049/jimmunol.1303125. Epub 2014 Apr 2.
T-cell depletion of bone marrow does not inhibit in vitro hematopoiesis.
Kirshner J, Ozer H, O'Leary M, Higby D, Marinello M, Preisler H.
Blut. 1985 Apr;50(4):201-8. doi: 10.1007/BF00320295.
Depletion of alphabeta(+) T cells for a haploidentical hematopoietic stem cell transplantation in children.
Choi ES, Im HJ, Kim H, Koh KN, Jang S, Park CJ, Seo JJ, Park HR.
J Clin Apher. 2018 Aug;33(4):521-528. doi: 10.1002/jca.21634. Epub 2018 Jul 3.
Transplantation. T-cell depletion--balancing acute rejection and cancer risk.
Reddy UG, Danovitch GM.
Nat Rev Nephrol. 2014 Jun;10(6):301-2. doi: 10.1038/nrneph.2014.61. Epub 2014 Apr 8.
